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Question: Multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient's own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.
| Patient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Before | 158 | 189 | 202 | 353 | 416 | 426 | 441 | | After | 284 | 214 | 101 | 227 | 290 | 176 | 290 |
Perform an appropriate test of hypothesis to determine if there is evidence, at the .05 level of significance, to support the claim that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant. What is the value of the sample test statistic?
Paired Test:The paired tests can be conducted in two ways. First, when subjects are repeated and observed under different conditions (repeated pair design) and second when subjects are paired based on a common feature (matched paired design).
Answer and Explanation:
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